ER stress boosts respiration
نویسندگان
چکیده
منابع مشابه
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.
Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The general mechanisms of the UPR and its apoptotic pathways are well characterized. However, the metabolic events that occur during the adaptive phase of ER stress, before the cell ...
متن کاملErratum Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
Increased mitochondrial Ca2+ drives the adaptive metabolic boost observed during early phases of ER stress Increases in mitochondrial respiration and ATP production are often consequences of increases in mitochondrial Ca2+ (Green and Wang, 2010). In order to determine whether early phases of ER stress induced by tunicamycin increased mitochondrial Ca2+ , we treated cells expressing cytosolic or...
متن کاملP42: Luteolin Counteracts ER Stress in PC12 Cells through Moderating ER Chaperones and Heat Shock Proteins
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملSugarcoating ER Stress
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
متن کاملEndoplasmic reticulum (ER) stress & diabetes.
The endoplasmic reticulum (ER) is a central organelle entrusted with lipid synthesis, protein folding and protein maturation. It is endowed with a quality control system that facilitates the recognition and targeting of aberrant proteins for degradation. When the capacity of this quality control system is exceeded, a stress response (ER stress) is switched on. Prolonged stress leads to apoptosi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2019
ISSN: 1471-0072,1471-0080
DOI: 10.1038/s41580-019-0139-x